ABSTRACT

Median blood creatinine (Qcr) is necessary for an accurate evaluation of geriatric renal function. Nonetheless, there is a significant void in existing literature concerning creatinine reference data unique to the elderly. To improve diagnostic precision and clinical decision-making in this susceptible group, this study developed a corresponding Q model for serum creatinine in geriatric patients stratified by age and sex. To determine the Qcr serum and reference range creatinine concentrations, 913 healthy elderly patients (452 males and 461 females) undergoing routine examinations at clinical laboratories were studied. Creatinine concentration reference intervals were divided into 3 age groups, namely: 60-69 years, 70-79 years, and >80 years. The median and percentiles p2.5 (lower reference limit/LRL) and p97.5 (upper reference limit/URL) were determined by the study. The study determined the Qcr serum creatinine and reference values for the elderly, stratified by age and sex.There were no significant differences observed in creatinine level across the age group, either in males or females. Males exhibited higher creatinine compared to females (p<0.05). These recently developed, age- and sex-stratified Qcr values are an invaluable tool for clinical laboratories, enabling more precise, tailored care for elderly patients with renal issues and enabling clinicians to more accurately assess geriatric renal function.

Keywords: Creatinine, reference interval, kidney function, non-communicable disease

INTRODUCTION

The prevalence of chronic kidney disease (CKD) is forty percent higher in geriatrics, making it a serious and expanding health concern in older populations.To date, there have been high cases of end-stage renal disease (ESRD) in the elderly that have increased by more than four times (20 percent).Chronicinflammation,cognitiveimpairment,anorexia, and other factors may contribute to the complex pathophysiology of CKD in the elderly.There is strong evidence that older adults with CKD are at a high risk of serious consequences, such as hospitalizations, ESRD, cardiovascular events, and even death. Therefore, it is critical to identify and treat kidney injury as soon as possible to slow the progression of CKD and eventually prevent the development of ESRD.

Accurate evaluation of geriatric renal function is essential for kidney disease early detection and 6treatment.Creatinine is a well-known indicator for evaluating kidney function. It has been shown that this endogenous marker is very helpful in identifying kidney diseases. Therefore, it is essential to establish reliable blood creatinine reference ranges that are The prevalence of chronic kidney disease (CKD) is age and sex specific. Clinicians can mitigate potential nephrotoxicity from medical interventions by using the serum creatinine reference range as a critical trigger for additional diagnostic evaluation and therapeutic intervention. These interventions could involve optimizing hydration status and closely monitoring the administration of medications.In addition to being useful for identifying kidney damage, serum creatinine levels are essential for managing CKD and drug dosage because they allow for the estimation of GFR (eGFR) and allow for more 7-9individualized patient care.The median creatinine (Qcr) has been widely used to normalize the significant factors affecting creatinine, including race, muscle mass, and geography. Seven factors were identified that significantly correlate with SCr reference values: latitude, annual sunshine duration, annual average temperature, annual average relative humidity, annual precipitation, annual temperature range, and topsoil (silt) cation exchange capacity. Therefore, Qcractsasa benchmark for understanding creatinine levels, particularly when looking at kidney function and eGFR using race-free formulas based on creatinine. Hence, the objective of this study is to establish reference intervals and Qcr for blood creatinine levels and Qcr by utilizing data from geriatrics.